Analysis Of The Inhibitory Ability Of Spike Attachment Of The Delta Variant Of Sars Cov-2 With Ace2 By The Active Compound In Turmeric (Curcuma longa L.) In Silico

Turmeric (Curcuma longa L.) is an herbal plant that has many benefits as a treatment, including during the COVID-19 pandemic, one of mechanisms inhibition SARS CoV-2 to inhibit attachment ACE2 with Spike. The binding spike protein receptor will produce conformational changes in S protein, this study was conducted using silico method (computational analysis) which aims determine potential efficacy and its effectiveness inhibiting Delta variant CoV-2. active compound contained L. ) obtained from KNApSAcK database To compounds can have good Variant CoV-2, analysis carried out by looking at energy conformation occur sticky point each compound. Three-dimensional structure Varian downloaded Protein Data Bank PDB code 7V8B. Based on out, it found (E)-nuciferoll lowest value -1212.59 kcal / mol located initial but cannot change conformation, (E)-nuciferol lies RBD-ACE2.